Generation of Human Soluble Leptin Receptor by Proteolytic Cleavage of Membrane-Anchored Receptors
نویسندگان
چکیده
منابع مشابه
Novel Regulatory Mechanisms for Generation of the Soluble Leptin Receptor: Implications for Leptin Action
BACKGROUND The adipokine leptin realizes signal transduction via four different membrane-anchored leptin receptor (Ob-R) isoforms in humans. However, the amount of functionally active Ob-R is affected by constitutive shedding of the extracellular domain via a so far unknown mechanism. The product of the cleavage process the so-called soluble leptin receptor (sOb-R) is the main binding protein f...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2001
ISSN: 0013-7227
DOI: 10.1210/en.142.10.4389